Brain natriuretic peptide as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.

ABSTRACT:

Introduction

Early identification of patients with sepsis at high risk of death remains a challenge, and whether brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) has a prognostic effect on patients with sepsis is controversial. Here, we clarified the prognostic value of BNP and NT-proBNP and sought to establish suitable cutoff values and intervals.

Methods

We searched five databases to identify studies that met the inclusion criteria. The primary outcomes were the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and corresponding 95% credible interval (95% CI) of BNP and NT-proBNP. The secondary outcomes were the sensitivity and s

SUBMITTER: Song JL 

PROVIDER: S-EPMC11304783 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature