Preparation of intrinsically fragile bent crystals.

ABSTRACT: Although molecular crystals have long been considered to be intrinsically brittle, a study of molecular crystals that are capable of plastic or elastic bending upon applying mechanical stress recently attracted significant attention. Malleable molecular crystals often need to meet specific criteria regarding the intermolecular interaction patterns within the crystal structure. Accordingly, examples have been reported where one polymorph shows bending, while other polymorphs of the same compound exhibit fracturing upon exposure to mechanical force. Here, we have succeeded in preparing bent crystals of an intrinsically fragile polymorph. Methylated flufenamic acid (1) can form three different polymorphs, i.e., 1α, 1β, and 1γ, of which 1β is difficult to isolate. Under mechanical force

SUBMITTER: Seki T 

PROVIDER: S-EPMC11304792 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature