Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila.

ABSTRACT:

Background

Many common diseases exhibit uncontrolled mTOR signaling, prompting considerable interest in the therapeutic potential of mTOR inhibitors, such as rapamycin, to treat a range of conditions, including cancer, aging-related pathologies, and neurological disorders. Despite encouraging preclinical results, the success of mTOR interventions in the clinic has been limited by off-target side effects and dose-limiting toxicities. Improving clinical efficacy and mitigating side effects require a better understanding of the influence of key clinical factors, such as sex, tissue, and genomic background, on the outcomes of mTOR-targeting therapies.

Results

We assayed gene expression with and without rapamycin exposure across three distinct body parts (head, thorax, abdomen) o

SUBMITTER: Raynes Y 

PROVIDER: S-EPMC11304892 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature