Stellate cells are in utero markers of pancreatic disease in cystic fibrosis.

ABSTRACT:

Background

Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of acinar tissue with cystic lesions and fibrosis is a progressive phenotype that may later lead to diabetes. Little is known about the initiating events in the fibrotic process though it may be a sequela of inflammation in the pancreatic ducts resulting from loss of CFTR impairing normal fluid secretion. Here we use a sheep model of CF (CFTR^-/-) to examine the evolution of pancreatic disease through gestation.

Methods

Fetal pancreas was collected at six time points from 50-days of gestation through to term, which is equivalent to ~ 13 weeks to term in human. RNA w

SUBMITTER: Leir SH 

PROVIDER: S-EPMC11304907 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature