Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development.

ABSTRACT:

Background

Monoamine oxidases (MAOs) is an enzyme that catalyzes the deamination of monoamines. The current research on this enzyme is focused on its role in neuropsychiatric, neurodevelopmental, and neurodegenerative diseases. Indeed, MAOs with two isoforms, namely, A and B, are located on the outer mitochondrial membrane and are widely distributed in the central nervous system and peripheral tissues. Several reports have described periodic changes in the levels of this enzyme in the human endometrial tissue.

Results

The novel role of MAOs in endometrial receptivity establishment and embryonic development by maintaining monoamine homeostasis was investigated in this study. MAOs activity was observed to be enhanced during the first trimester in both humans and mice under nor

SUBMITTER: Yu Z 

PROVIDER: S-EPMC11304925 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature