Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.

ABSTRACT:

Background

Increasing functional residual capacity (FRC) or tidal volume (V_T) reduces airway resistance and attenuates the response to bronchoconstrictor stimuli in animals and humans. What is unknown is which one of the above mechanisms is more effective in modulating airway caliber and whether their combination yields additive or synergistic effects. To address this question, we investigated the effects of increased FRC and increased V_T in attenuating the bronchoconstriction induced by inhaled methacholine (MCh) in healthy humans.

Methods

Nineteen healthy volunteers were challenged with a single-dose of MCh and forced oscillation was used to measure inspiratory resistance at 5 and 19 Hz (R₅ and R₁₉), their difference (R_5-19<

SUBMITTER: Gobbi A 

PROVIDER: S-EPMC11304934 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature