Radio-miRs: a comprehensive view of radioresistance-related microRNAs.

ABSTRACT: Radiotherapy is a key treatment option for a wide variety of human tumors, employed either alone or alongside with other therapeutic interventions. Radiotherapy uses high-energy particles to destroy tumor cells, blocking their ability to divide and proliferate. The effectiveness of radiotherapy is due to genetic and epigenetic factors that determine how tumor cells respond to ionizing radiation. These factors contribute to the establishment of resistance to radiotherapy, which increases the risk of poor clinical prognosis of patients. Although the mechanisms by which tumor cells induce radioresistance are unclear, evidence points out several contributing factors including the overexpression of DNA repair systems, increased levels of reactive oxygen species, alterations in the tumor microen

SUBMITTER: Pedroza-Torres A 

PROVIDER: S-EPMC11304977 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature