Potentially actionable targets in synovial sarcoma: A tissue microarray study.

ABSTRACT:

Background

Synovial sarcoma (SynSa) is one of the most common translocation-related soft tissue sarcomas. Patients with metastatic SynSa have limited treatment options and a very poor prognosis. Several novel experimental therapies are currently being explored in clinical trials, including T cell-based therapies targeting cancer testis antigens such as New York esophageal squamous cell carcinoma 1 (NY-ESO-1) or melanoma-associated antigen A4 (MAGE-A4), and degraders targeting bromodomain-containing protein 9 (BRD9). Preclinical studies investigate inhibitors of Yes associated protein 1 (YAP1), transcriptional co-activator with PDZ-binding motif (TAZ) and inhibitors of chemokine receptor 4 (CXCR4).

Methods

We explored the immunohistochemical expression of these targets using

SUBMITTER: De Cock L 

PROVIDER: S-EPMC11305002 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature