Impaired sensitivity to thyroid hormone correlates to all-cause mortality in euthyroid individuals with chronic kidney disease.

ABSTRACT:

Background

This study aimed to investigate the association between central sensitivity to thyroid hormones and all-cause mortality in euthyroid patients with chronic kidney disease (CKD).

Methods

​Data on thyroid function indicators and all-cause mortality for CKD patients were extracted from the NHANES database (2007-2012). Central sensitivities to thyroid hormones were mainly evaluated by Thyroid Feedback Quantile-based Index (TFQI). The Kaplan-Meier method, Cox proportional hazards regression model and subgroup analysis were performed to explore the potential associations between thyroid hormone sensitivity and all-cause mortality.

Results

A total of 1303 euthyroid CKD patients were enrolled in this study. After a median follow-up of 115 months, 503 participants di

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11305014 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature