A highly fluorescent and readily accessible all-organic photosensitizer model for advancing image-guided cancer PDT.

ABSTRACT: The potential of using image-guided photodynamic therapy (ig-PDT) for cancer, especially with highly biocompatible fluorescent agents free of heavy atoms, is well recognized. This is due to key advantages related to minimizing adverse side effects associated with standard cancer chemotherapy. However, this theragnostic approach is strongly limited by the lack of synthetically-accessible and easily-modulable chemical scaffolds, enabling the rapid design and construction of advanced agents for clinical ig-PDT. In fact, there are still very few ig-PDT agents clinically approved. Herein we report a readily accessible, easy-tunable and highly fluorescent all-organic small photosensitizer, as a model design for accelerating the development and translation of advanced ig-PDT agents for cancer. Th

SUBMITTER: Garcia-Sampedro A 

PROVIDER: S-EPMC11305095 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature