Iron oxide nanozymes enhanced by ascorbic acid for macrophage-based cancer therapy.

ABSTRACT: In recent years, using pharmacological ascorbic acid has emerged as a promising therapeutic approach in cancer treatment, owing to its capacity to induce extracellular hydrogen peroxide (H₂O₂) production in solid tumors. The H₂O₂ is then converted into cytotoxic hydroxyl free radicals (HO˙) by redox-active Fe²⁺ inside cells. However, the high dosage of ascorbic acid required for efficacy is hampered by adverse effects such as kidney stone formation. In a recent study, we demonstrated the efficient catalytic conversion of H₂O₂ to HO˙ by wüstite (Fe_1-xO) nanoparticles (WNPs) through a heterogenous Fenton reaction. Here, we explore whether WNPs can enhance the therapeutic potential of ascorbic acid,

SUBMITTER: Yi Z 

PROVIDER: S-EPMC11305150 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature