Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity.

ABSTRACT:

Background

Biliary tract cancers (BTCs) exhibit high mortality rates and significant heterogeneity in both clinical and molecular characteristics. This study aims to molecularly characterize a cohort of patients with BTC, with a specific focus on genomic alterations within homologous recombination repair (HRR) genes in a real-world setting.

Patients and methods

We carried out a retrospective analysis on 256 patients with BTC treated at five Austrian centers and one German comprehensive cancer center between 2016 and 2023 utilizing comprehensive genomic profiling platforms to assess HRR status and its correlation with clinical outcomes after platinum-based chemotherapy.

Results

A total of 67 patients (27.5%) exhibited HRR gene mutations (HRRm), with the most common pat

SUBMITTER: Mavroeidi IA 

PROVIDER: S-EPMC11305189 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature