Role of the polyamine transporter PotABCD during biofilm formation by Streptococcus pneumoniae.

ABSTRACT: Streptococcus pneumoniae is a bacterium of great global importance, responsible for more than one million deaths per year. This bacterium is commonly acquired in the first years of life and colonizes the upper respiratory tract asymptomatically by forming biofilms that persist for extended times in the nasopharynx. However, under conditions that alter the bacterial environment, such as viral infections, pneumococci can escape from the biofilm and invade other niches, causing local and systemic disease of varying severity. The polyamine transporter PotABCD is required for optimal survival of the organism in the host. Immunization of mice with recombinant PotD can reduce subsequent bacterial colonization. PotD has also been suggested to be involved in pneumococcal biofilm development. Theref

SUBMITTER: Vieira B 

PROVIDER: S-EPMC11305561 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature