Electrical stimulation of Schwann cells on electrospun hyaluronic acid carbon nanotube fibers.

ABSTRACT: Neurofibromatosis Type 1 (NF1) is a complex genetic disorder characterized by the development of benign neurofibromas, which can cause significant morbidity in affected individuals. While the molecular mechanisms underlying NF1 pathogenesis have been extensively studied, the development of effective therapeutic strategies remains a challenge. This paper presents the development and validation of a novel biomaterial testing model to enhance our understanding of NF1 pathophysiology, disease mechanisms and evaluate potential therapeutic interventions. Our long-term goal is to develop an invitro model of NF1 to evaluate drug targets. We have developed an in vitro system to test the cellular behavior of NF1 patient derived cells on electroconductive aligned nanofibrous biomaterials with electri

SUBMITTER: Senanayake J 

PROVIDER: S-EPMC11305570 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature