Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes.

ABSTRACT: Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection management. This study explores the role of the flexible genome, organised in regions of genomic plasticity (RGP), in shaping the pathogenicity of Salmonella lineages. Through comprehensive genomic analysis of 12,244 Salmonella spp. genomes covering 2 species, 6 subspecies, and 46 serovars, we uncover distinct integration patterns of pathogenicity-related gene clusters into RGP, challenging traditional views of gene distribution. These RGP exhibit distinct preferences for specific genomic spots, and the presence or absence of such spots across Salmonella lineages profoundly shapes strain pathogenicity. RGP preferences are guided by conserved flanking genes surrounding integration spots, implicating

SUBMITTER: Krishnakant Kushwaha S 

PROVIDER: S-EPMC11305592 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature