Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice.

ABSTRACT: CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes of murine Treg and conventional T cells (Tconv), we observe that the proenkephalin gene (Penk), encoding the precursor of analgesic opioid peptides, ranks among the top 25 genes most enriched in Treg cells. We then present various evidence suggesting that Penk is regulated in part by members of the Tumor Necrosis Factor Receptor (TNFR) family and the transcription factor Basic leucine zipper transcription faatf-like (BATF). Using mice in which the promoter activity of Penk can be tra

SUBMITTER: Aubert N 

PROVIDER: S-EPMC11305673 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature