Association between bronchial asthma and TSLP gene polymorphism: a systematic review and meta-analysis.

ABSTRACT:

Aims

This study entails an association between bronchial asthma and common single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) gene; rs2289278, rs3806933, rs2289276, and rs1837253.

Methods

The databases of PubMed, Embase, Web of Science, and Google Scholar were searched for studies reporting TSLP polymorphisms and asthma from inception to January 2022. Hardy-Weinberg equilibriums (HWE) for each polymorphism of the control group were checked using the χ ² test. The association was estimated by means of odds ratio (OR) with 95% CI in both dominant and recessive modes of inheritance, respectively.

Results

Altogether, 11 studies with 3121 asthma cases and 3041 healthy controls were added. Results from six studies showed that the

SUBMITTER: Shrestha AB 

PROVIDER: S-EPMC11305796 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature