Dataset Information

Long-Term Effects of the Multicomponent Program BrainProtect^® on Cognitive Function: One-Year Follow-Up in Healthy Adults.

ABSTRACT:

Background

Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer's disease is still debated.

Objective

To investigate the long-term effects of the eight-week multicomponent training program BrainProtect^® on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.

Methods

Healthy adults (age ≥50 years) previously randomized to either GHC (n = 72) or BrainProtect (intervention group, IG, n = 60) for eight-weeks (once weekly, 90 minutes, group-based) underwent a comprehensive neuropsychological test battery and health-related quality of life (HRQoL) evaluation 3- and 12-months after intervention end.

Results

Dropout rates were n = 8 after 3 months and n = 19 after 12 months. No significant long-term effect of BrainProtect was observed for the primary endpoint Consortium to Establish a Registry for Alzheimer's Disease (CERAD-Plus) total score. Logical reasoning was significantly improved (p = 0.024) 12 months after completion of the training program in IG participants compared to the GHC group independent of sex, age, education, diet, and physical activity. In IG participants, thinking flexibility (p = 0.019) and confrontational naming (p = 0.010) were improved 3 months after completing the intervention compared to the GHC group, however, after conservative Bonferroni adjustment, significance was lost.

Conclusions

BrainProtect^® independently improved logical reasoning compared to GHC up to 12 months after cognitive training's end in healthy adults. To uncover the long-term clinical significance of multicomponent cognitive training in healthy adults, studies with larger sample size and frequent follow up visits are necessary.

SUBMITTER: Kunkler MC

PROVIDER: S-EPMC11305852 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Long-Term Effects of the Multicomponent Program BrainProtect<sup>®</sup> on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Kunkler Michelle Celine MC Falkenreck Julia Maria JM Ophey Anja A Dencker Katharina K Friese Andrea A Jahr Petra P Kalbe Elke E Nelles Gereon G Polidori M Cristina MC

Journal of Alzheimer's disease reports 20240718 1

<h4>Background</h4>Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer's disease is still debated.<h4>Objective</h4>To investigate the long-term effects of the eight-week multicomponent training program BrainProtect<sup>®</sup> on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.<h4>Methods</h4>Healthy adults (age ≥5 ...[more]

PMID: 39114551

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Project description:BackgroundThe causes of valvular disease in China are complex, with a broad age distribution. For patients with early mechanical valve replacement, the quality of life is affected by postoperative anticoagulation-related complications. Since 2005, we have used bioprosthetic valves to provide more options for patients. In this study, we retrospectively analyzed the 14-year follow-up data of patients undergoing BalMedic bovine pericardial bioprosthetic valve replacement (manufacturer: Beijing Balance Medical Tech Co., Ltd.) to evaluate its intermediate- to long-term clinical effectiveness.MethodsFrom 2005 to 2014, 336 BalMedic pericardial bioprosthesis valves were implanted in 299 patients (mean age 53.5 years, 59.86% female) at The First People's Hospital of Yulin. Among followed up 290 discharged patients, 284 underwent aortic valve replacement and mitral valve replacement (AVR group, MVR group) for further grouping analysis, 6 underwent tricuspid valve replacement (TVR). The mean follow-up was 7.7±2.5 years (5 to 14), for a total of 2,196 valve-years, 98.28% of the patients completed follow-up.ResultsThe perioperative mortality was 3% (9/299). After discharge, 68 patients (23.4%, 68/290) died, and 36 (12.4% 36/290) underwent the second valve replacement. The overall 5- and 10-year survival rates were 89.95% and 72.53%, respectively. For patients undergoing AVR alone, the overall 10-year survival rates were 80.64%, the reoperation-free rates were 92.94%, and the SVD-free rates were 90.95%. For patients undergoing MVR and double valve replacement (DVR group), the 10-year survival rates were 67.21% and 82.90%, the reoperation-free rates were 72.26% and 73.33%, the SVD-free rates were 58.90% and 53.80%, respectively. Subgroup analysis by age showed no significant intergroup difference in overall survival but a significant intergroup difference in reoperation-free and SVD-free rates (P<0.05).ConclusionsWith a similar 10-year overall survival rate as its foreign counterparts, BalMedic bovine pericardial bioprosthesis is reliable choice for both aortic valve and mitral valve. In patients undergoing AVR, the BalMedic valve is superior to the similar foreign counterparts in overall survival, reoperation-free survival, and SVD-free rates. While in MVR or DVR, Chinese patients are younger because of different etiology, postoperative outcomes show non-inferior to those from the foreign counterparts.

Dataset Information

Long-Term Effects of the Multicomponent Program BrainProtect^® on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Background

Objective

Methods

Results

Conclusions

Publications

Long-Term Effects of the Multicomponent Program BrainProtect<sup>®</sup> on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Long-Term Effects of the Multicomponent Program BrainProtect® on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Background

Objective

Methods

Results

Conclusions

Publications

Long-Term Effects of the Multicomponent Program BrainProtect<sup>®</sup> on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Long-Term Effects of the Multicomponent Program BrainProtect^® on Cognitive Function: One-Year Follow-Up in Healthy Adults.