Rumination and Overrecruitment of Cognitive Control Circuits in Depression.

ABSTRACT:

Background

Rumination is associated with greater cognitive dysfunction and treatment resistance in major depressive disorder (MDD), but its underlying neural mechanisms are not well understood. Because rumination is characterized by difficulty in controlling negative thoughts, the current study investigated whether rumination was associated with aberrant cognitive control in the absence of negative emotional information.

Methods

Individuals with MDD (n = 176) and healthy control individuals (n = 52) completed the stop signal task with varied stop signal difficulty during functional magnetic resonance imaging. In the task, a longer stop signal asynchrony made stopping difficult (hard stop), whereas a shorter stop signal asynchrony allowed more time for stopping (easy stop).

SUBMITTER: Park H 

PROVIDER: S-EPMC11305927 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature