Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis.

ABSTRACT:

Background

The Index of Severity for Eosinophilic Esophagitis (I-SEE) is a new expert-defined clinical tool that classifies disease severity of eosinophilic esophagitis (EoE).

Objective

We aimed to determine whether I-SEE is associated with patient characteristics, molecular features of EoE, or both.

Methods

We analyzed a prospective cohort of patients with EoE from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Associations between I-SEE and clinical and molecular features (assessed by an EoE diagnostic panel [EDP]) were assessed.

Results

In 318 patients with chronic EoE (209 adults, 109 children), median total I-SEE score was 7.0, with a higher symptoms and complications score in children than adults (4.0 vs 1.0; P < .001) and hi

SUBMITTER: Sato H 

PROVIDER: S-EPMC11305930 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature