Unraveling the causal link: fatty acids and inflammatory bowel disease.

ABSTRACT:

Background

Previous observational studies have revealed the strong relationship between fatty acids (FA) and inflammatory bowel disease (IBD). Nonetheless, due to the inherent limitations of retrospective research, the causality between the two has not been clearly established.

Methods

Genetic variants associated with the 17 FA indicators were derived from genome-wide association studies. Summary statistics for the discovery cohort and testing cohort for IBD, including ulcerative colitis (UC) and Crohn's disease (CD), were available from IIBDGC and FinnGen, respectively. Bidirectional MR analysis and sensitivity analysis with multiple measures were applied to comprehensively investigate the causal link between FA and IBD.

Results

Combining the results of various MR me

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11306040 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature