Causal associations of fatigue and functional outcome after ischemic stroke: a mediation Mendelian randomization study.

ABSTRACT:

Background and objectives

Fatigue has been associated with adverse effects on recovery from ischemic stroke based on previous observational research. The purpose of our study was to explore the potential causal association of fatigue with poor functional outcome after ischemic stroke by employing Mendelian randomization (MR).

Methods

A set of instrumental variables, comprising 36 single-nucleotide polymorphisms (SNPs) that are only related to fatigue, were derived from a genome-wide association study (GWAS) that included 449,019 general individuals. The functional outcomes after ischemic stroke were derived from a GWAS (Genetics of Ischemic Stroke Functional Outcome Network) involving 6,021 survivors. Two-sample MR methods were used to assess the causal effect, including inv

SUBMITTER: Jiang P 

PROVIDER: S-EPMC11306070 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature