Sex-specific association of circulating Isthmin-1 with isolated post-challenge hyperglycemia.

ABSTRACT:

Introduction

To explore the distribution of Isthmin-1 (ISM1) level and its association with isolated post-challenge hyperglycemia (IPH).

Methods

A total of 522 participants without a history of diabetes were invited to attend a standard 75g 2-h oral glucose tolerance test (OGTT), and 71 subjects were further invited for a 3-h oral minimal model test. Insulin sensitivity and β-cell function were evaluated using both HOMA and estimated from OGTT. Circulating ISM1 levels were determined by a commercially available ELISA kit.

Results

A total of 76 (14.6%) participants were diagnosed as IPH, accounting for 61.3% of the newly diagnosed diabetes. ISM1 levels were significantly higher in men than in women (1.74 ng/mL versus 0.88 ng/mL). The inverse correlation between

SUBMITTER: Fan J 

PROVIDER: S-EPMC11306075 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature