Diterpenoids target SARS-CoV-2 RdRp from the roots of Euphorbia fischeriana Steud.

ABSTRACT:

Introduction

Currently, the development of new antiviral drugs against COVID-19 remains of significant importance. In traditional Chinese medicine, the herb Euphorbia fischeriana Steud is often used for antiviral treatment, yet its therapeutic effect against the COVID-19 has been scarcely studied. Therefore, this study focuses on the roots of E. fischeriana Steud, exploring its chemical composition, antiviral activity against COVID-19, and the underlying basis of its antiviral activity.

Methods

Isolation and purification of phytochemicals from E. fischeriana Steud. The elucidation of their configurations was achieved through a comprehensive suite of 1D and 2D NMR spectroscopic analyses as well as X-ray diffraction. Performed cytopathic effect assays of S

SUBMITTER: Ruan T 

PROVIDER: S-EPMC11306077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature