Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity.

ABSTRACT:

Introduction

Enteric glial cells are important players in the control of motility, intestinal barrier integrity and inflammation. During inflammation, they switch into a reactive phenotype enabling them to release inflammatory mediators, thereby shaping the inflammatory environment. While a plethora of well-established in vivo models exist, cell culture models necessary to decipher the mechanistic pathways of enteric glial reactivity are less well standardized. In particular, the composition of extracellular matrices (ECM) can massively affect the experimental outcome. Considering the growing number of studies involving primary enteric glial cells, a better understanding of their homeostatic and inflammatory in vitro culture conditions is needed.

Methods

We exa

SUBMITTER: Schneider L 

PROVIDER: S-EPMC11306135 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature