Association between genetically plasma proteins and osteonecrosis: a proteome-wide Mendelian randomization analysis.

ABSTRACT:

Background

Previous studies have explored the role of plasma proteins on osteonecrosis. This Mendelian randomization (MR) study further assessed plasma proteins on osteonecrosis whether a causal relationship exists and provides some evidence of causality.

Methods

Summary-level data of 4,907 circulating protein levels were extracted from a large-scale protein quantitative trait loci study including 35,559 individuals by the deCODE Genetics Consortium. The outcome data for osteonecrosis were sourced from the FinnGen study, comprising 1,543 cases and 391,037 controls. MR analysis was conducted to estimate the associations between protein and osteonecrosis risk. Additionally, Phenome-wide MR analysis, and candidate drug prediction were employed to identify potential causal circu

SUBMITTER: Meng C 

PROVIDER: S-EPMC11306153 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature