A diet-wide Mendelian randomization analysis: causal effects of dietary habits on type 2 diabetes.

ABSTRACT:

Background

Traditional clinical studies have indicated a link between certain food intakes and type 2 diabetes (T2D), but the causal relationships between different dietary habits and T2D remain unknown. Using Mendelian randomization (MR) approaches, we investigated the potential causal association between dietary habits and T2D risk.

Methods

We collected publicly available genome-wide association studies' summary statistics for 18 dietary habits from the UK Biobank and T2D data from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium. We applied the inverse variance weighted (IVW) method, supplemented with the MR-Egger method, weighted median method (WMM), simple method, weighted mode, MR-Egger regression, and the MR pleiotropy residual sum and outlier

SUBMITTER: Xiao R 

PROVIDER: S-EPMC11306177 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature