Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication.

ABSTRACT:

Introduction

Oxysterol-binding protein (OSBP) is known for its crucial role in lipid transport, facilitating cholesterol exchange between the Golgi apparatus and endoplasmic reticulum membranes. Despite its established function in cellular processes, its involvement in coronavirus replication remains unclear.

Methods

In this study, we investigated the role of OSBP in coronavirus replication and explored the potential of a novel OSBP-binding compound, ZJ-1, as an antiviral agent against coronaviruses, including SARS-CoV-2. We utilized a combination of biochemical and cellular assays to elucidate the interactions between OSBP and SARS-CoV-2 non-structural proteins (Nsps) and other viral proteins.

Results

Our findings demonstrate that OSBP positively regulates coronaviru

SUBMITTER: Ma-Lauer Y 

PROVIDER: S-EPMC11306179 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature