The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis.

ABSTRACT:

Introduction

Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), which involves various epigenetic modifications.

Objectives

N⁶-methyladenosine (m⁶A), the most prevalent RNA modification in eukaryotic cells, influences numerous physiological and pathological processes. Nevertheless, the role of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), a reader gene mediating m⁶A modifications, in liver fibrosis remains unclear.

Methods and results

This study demonstrated that IGF2BP3 knockout reduces liver fibrosis by promoting HSC ferroptosis (FPT) and inactivating HSCs. Multi-omics analysis revealed that HSC-specific IGF2BP3 knockout decreased m⁶A content in Jagged1 (Jag1), a key com

SUBMITTER: Li X 

PROVIDER: S-EPMC11306284 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature