Proteome-wide Characterization and Pathophysiology Correlation in Non-ischemic Cardiomyopathies.

ABSTRACT:

Background and objectives

Although the clinical consequences of advanced heart failure (HF) may be similar across different etiologies of cardiomyopathies, their proteomic expression may show substantial differences in relation to underlying pathophysiology. We aimed to identify myocardial tissue-based proteomic characteristics and the underlying molecular pathophysiology in non-ischemic cardiomyopathy with different etiologies.

Methods

Comparative extensive proteomic analysis of the myocardium was performed in nine patients with biopsy-proven non-ischemic cardiomyopathies (3 dilated cardiomyopathy [DCM], 2 hypertrophic cardiomyopathy [HCM], and 4 myocarditis) as well as five controls using tandem mass tags combined with liquid chromatography-mass spectrometry. Differential

SUBMITTER: Lee S 

PROVIDER: S-EPMC11306425 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature