Bidirectional Mendelian randomization to explore the causal relationships between the gut microbiota and male reproductive diseases.

ABSTRACT: Gut bacteria might play an important role in male reproductive disorders, such as male infertility and sperm abnormalities; however, their causal role is unclear. Herein, Mendelian randomization (MR)-Egger, weighted median, inverse variance weighting, Simple mode, and Weighted mode were used to test the causal relationship between gut microbes and male reproductive diseases. The MR results were validated using various metrics. The MR results were also consolidated using reverse causality speculation, conducted using two-way MR analysis and Steiger filtering. Biological function was analysed using enrichment analyses. The results suggested that eight intestinal microflorae were causally associated with male infertility. The Eubacterium oxidoreducens group was associated with an increased ri

SUBMITTER: Han X 

PROVIDER: S-EPMC11306555 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature