Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice.

ABSTRACT: Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration. Multiple pathomolecular processes contribute to neuroinflammation, oligodendrocyte cell death, and progressive neuronal dysfunction. In this study, we use the cuprizone mouse model of demyelination to investigate long-term non-invasive gamma entrainment using sensory stimulation as a potential therapeutic intervention for promoting myelination and reducing neuroinflammation in male mice. Here, we show that multisensory gamma stimulation mitigates demyelination, promotes olig

SUBMITTER: Rodrigues-Amorim D 

PROVIDER: S-EPMC11306744 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature