Preservatives for postmortem brain tissue in biomechanical testing: A pilot study.

ABSTRACT: Postmortem human subject (PMHS) studies are essential to brain injury research in motor vehicle safety. However, postmortem deterioration reduces the similarity between postmortem test results and in vivo response in material testing of brain tissue and in biomechanical testing of the whole head. This pilot study explores the effect of potential preservatives on brain tissue breakdown to identify promising preservatives that warrant further investigation. To identify preservatives with potential to slow postmortem degradation, samples from an initial PMHS were refrigerated at 10°C to qualitatively compare tissue breakdown from 58 to 152 h postmortem after storage in candidate solutions. On brain tissue samples from a second PMHS, compressive stiffness was measured on six samples immediatel

SUBMITTER: Mallory A 

PROVIDER: S-EPMC11306769 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature