Assessment of performance of the profilers provided in the OECD QSAR toolbox for category formation of chemicals.

ABSTRACT: Growing restrictions and bans on animal testing for chemical safety assessment under different regulations have led to an increasing use of alternative methods. Read-across is one of the major approaches used for this purpose, which relies on the identification of toxicological hazards of a data-poor or untested (target) chemical from data on other already-tested (source) similar chemicals. This requires the target substance to be first assigned to a group or category of 'similar' chemicals. The 'similarity' may be in terms of structural features alone, or in combination with certain rules that are based on mechanistic and/or toxicological aspects. In this regard, the OECD QSAR toolbox-a major free-access in silico platform-is widely used to derive toxicity predictions for a range of (eco)

SUBMITTER: Aljallal MA 

PROVIDER: S-EPMC11306771 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature