Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury in mice.

ABSTRACT: Sepsis is a critical global health concern linked to high mortality rates, often due to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). While the gut-lung axis involvement in ALI is recognized, direct migration of gut immune cells to the lung remains unclear. Our study reveals sepsis-induced migration of γδ T17 cells from the small intestine to the lung, triggering an IL-17A-dominated inflammatory response in mice. Wnt signaling activation in alveolar macrophages drives CCL1 upregulation, facilitating γδ T17 cell migration. CD44⁺ Ly6C^- IL-7R^high CD8^low cells are the primary migratory subtype exacerbating ALI. Esketamine attenuates ALI by inhibiting pulmonary Wnt/β-catenin signaling-mediated migration. This work underscores the

SUBMITTER: Xie B 

PROVIDER: S-EPMC11306781 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature