RECIST 1.1 assessments variability: a systematic pictorial review of blinded double reads.

ABSTRACT: Reader variability is intrinsic to radiologic oncology assessments, necessitating measures to enhance consistency and accuracy. RECIST 1.1 criteria play a crucial role in mitigating this variability by standardizing evaluations, aiming to establish an accepted "truth" confirmed by histology or patient survival. Clinical trials utilize Blind Independent Centralized Review (BICR) techniques to manage variability, employing double reads and adjudicators to address inter-observer discordance effectively. It is essential to dissect the root causes of variability in response assessments, with a specific focus on the factors influencing RECIST evaluations. We propose proactive measures for radiologists to address variability sources such as radiologist expertise, image quality, and accessibility

SUBMITTER: Iannessi A 

PROVIDER: S-EPMC11306910 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature