Identification of potential therapeutic targets for skin cutaneous melanoma on the basic of transcriptomics.

ABSTRACT:

Background

Advanced skin cutaneous melanoma (SKCM) is responsible for the majority of skin cancer-related deaths. Apart from the rare BRAF V600F mutation, which can be targeted with specific drugs, there are currently no other novel effective therapeutic targets.

Methods

We used SMR analysis with cis-expressed quantitative trait locus (cis-eQTL) as the exposure variable and SKCM as the outcome variable to identify potential therapeutic targets for SKCM. Colocalization assays and HEIDI tests are used to test whether SKCM risk and gene expression are driven by common SNPs. Replication analysis further validated the findings, and we also constructed protein-protein interaction networks to explore the relationship between the identified genes and known SKCM targets. Drug predict

SUBMITTER: Shi F 

PROVIDER: S-EPMC11306917 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature