Molecular Epidemiology of Isoniazid-resistant <i>M tuberculosis</i> in Port-au-Prince, Haiti.

ABSTRACT:

Background

Isoniazid-resistant, rifampin-susceptible tuberculosis (Hr-TB) is associated with poor treatment outcomes and higher rates of acquisition of further drug resistance during treatment. Due to a lack of widespread diagnostics, Hr-TB is frequently undetected and its epidemiology is incompletely understood.

Methods

We studied the molecular epidemiology of Hr-TB among all patients diagnosed with culture-positive pulmonary tuberculosis between January 1 and June 30, 2017, at an urban referral tuberculosis clinic in Port-au-Prince, Haiti. Demographic and clinical data were extracted from the electronic medical record. Archived diagnostic Mycobacterium tuberculosis isolates were tested for genotypic and phenotypic isoniazid resistance using the Genotype MTBDRplus

SUBMITTER: Walsh KF 

PROVIDER: S-EPMC11306977 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature