Impact of Physical Exercise on Levodopa Therapy Across Parkinson's Disease Stages.

ABSTRACT:

Background

Levodopa is the gold standard of treatment in Parkinson's disease (PD). Its clinical effect changes as the disease progresses. Wearing off is a frequent first manifestation of motor fluctuations. Some patients with advanced PD report faster wearing off after physical exercise.

Objective

The aim was to assess if pharmacokinetics of levodopa is influenced by physical exercise in patients with different disease advancement.

Methods

22 patients with PD (12 untreated with levodopa and 10 with motor fluctuations) and 7 healthy controls (HC) were included. Plasma samples were collected at 9 fixed timepoints following administration of levodopa/benserazide 200/50 mg for two days: rest day and standardized physical exercise day. Clinical assessment with Unified Park

SUBMITTER: Figura M 

PROVIDER: S-EPMC11307027 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature