Classifying Alzheimer's Disease Neuropathology Using Clinical and MRI Measurements.

ABSTRACT:

Background

Computer-aided machine learning models are being actively developed with clinically available biomarkers to diagnose Alzheimer's disease (AD) in living persons. Despite considerable work with cross-sectional in vivo data, many models lack validation against postmortem AD neuropathological data.

Objective

Train machine learning models to classify the presence or absence of autopsy-confirmed severe AD neuropathology using clinically available features.

Methods

AD neuropathological status are assessed at postmortem for participants from the National Alzheimer's Coordinating Center (NACC). Clinically available features are utilized, including demographics, Apolipoprotein E(APOE) genotype, and cortical thicknesses derived from ante-mortem MRI scans encompassing

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC11307063 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature