Citicoline: A Cholinergic Precursor with a Pivotal Role in Dementia and Alzheimer's Disease.

ABSTRACT:

Background

Citicoline is a naturally occurring compound with pleiotropic effects on neuronal function and cognitive processes.

Objective

Based on previous studies, which shed light on the positive effects of citicoline 1 g when combined with acetylcholinesterase inhibitors (AChEIs) and/or memantine, we further investigated the benefits of citicoline in combination therapy in Alzheimer's disease and mixed dementia.

Methods

We integrated the datasets of CITIMEM and CITIDEMAGE, increasing the overall sample size to enhance statistical power. We analyzed data from these two investigator-initiated studies involving 295 patients. The primary outcome was the assessment over time of the effects of combined treatment versus memantine given alone or AChEI plus memantine on cogn

SUBMITTER: Gareri P 

PROVIDER: S-EPMC11307077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature