Lignan Intake and Type 2 Diabetes Incidence Among US Men and Women.

ABSTRACT:

Importance

Lignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.

Objective

To prospectively investigate associations between lignan intake and T2D incidence.

Design, setting, and participants

Population-based cohort study of US men and women enrolled in the Nurses' Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well as 496 participants from the Men's Lifestyle Validation Study (MLVS). Participants were free of T2D, cardiovascular disease, and cancer at baseline. Data were analyzed from November 2022 to July 2023.

Exposures

Total and individual lignans were assessed using a validated food frequency questionnaire, which was updated every 2 to 4

SUBMITTER: Wang S 

PROVIDER: S-EPMC11307137 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature