Proangiogenic Growth Factor Therapy for the Treatment of Refractory Angina: A Meta-analysis.

ABSTRACT:

Background

Refractory angina (RFA; limiting angina despite optimal medical therapy) is a growing, global problem, with limited treatment options. Therefore, we conducted a systematic review of randomized controlled trials (RCTs) to evaluate the effect of proangiogenic growth factor therapy (in the form of vascular growth factors delivered either as recombinant proteins or gene therapy) in patients with RFA ineligible for revascularization.

Methods

We performed a meta-analysis (PROSPERO: CRD42018107283) of RCTs as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. A comprehensive search of the PubMed, CENTRAL, Embase, Cochrane, ClinicalTrials.gov and Google Scholar databases, as well as scientific session abstracts, were performed. The poo

SUBMITTER: Weeraman D 

PROVIDER: S-EPMC11307391 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature