The Burden of Nonalcoholic Steatohepatitis: A Systematic Review of Epidemiology Studies.

ABSTRACT:

Background and aims

Nonalcoholic steatohepatitis (NASH) is associated with increased mortality and risk of complications but is often asymptomatic and under-recognized. A systematic review of NASH epidemiology was conducted to provide information on the burden of NASH and highlight important evidence gaps for future research.

Methods

Medline, EMBASE, and Cochrane Library databases were searched for English-language publications published from 2010 to January 2022 that reported on natural history, risk factors, comorbidities, and complications of a NASH population or subpopulation.

Results

Overall, 173 publications were included. NASH was shown to have a variable disease course and high prevalence of comorbid disease. Although many patients progressed to cirrhosis and

SUBMITTER: Tapper EB 

PROVIDER: S-EPMC11307414 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature