Early Deregulation of Cholangiocyte NR0B2 During Primary Sclerosing Cholangitis.

ABSTRACT:

Background and aims

Primary sclerosing cholangitis (PSC) is a probable autoimmune liver disease characterized by persistent and progressive biliary inflammation that leads to biliary infection, cirrhosis, or cholangiocarcinoma. Genome-wide omics data are scarce regarding this severe disease.

Methods

MEDLINE database gene prioritization by text mining (biliary inflammation, biliary fibrosis, biliary stasis) was integrated in distinct omics data: (1) PSC liver transcriptome training and validation cohorts, (2) farnesoid X receptor (FXR) mice liver transcriptome subjected to an FXR agonist or FXR knockout mice; (3) liver single-cell transcriptome of the Abcb4-/- mice model of PSC.

Results

A liver molecular network highlighted the involvement of nuclear receptor subfamily

SUBMITTER: Desterke C 

PROVIDER: S-EPMC11307415 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature