Regulation of Parietal Cell Homeostasis by Bone Morphogenetic Protein Signaling.

ABSTRACT:

Background and aims

Loss of bone morphogenetic protein (BMP) signaling in the stomach, achieved by transgenic expression of the BMP inhibitor noggin (H ⁺ /K ⁺ -Nog mice), causes parietal cell (PC) loss, spasmolytic polypeptide-expressing metaplasia, a marker of preneoplasia, and activation of cell proliferation. We examined if specific inhibition of BMP signaling in PCs leads to aberrations in epithelial homeostasis.

Methods

Mice with floxed alleles of BMP receptor 1a (Bmpr1a ^flox/flox mice) were crossed to H ⁺ /K ⁺ -Cre mice to generate H ⁺ /K ⁺ -Cre;Bmpr1a ^flox/flox

SUBMITTER: Takabayashi H 

PROVIDER: S-EPMC11307507 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature