Successful Manipulation of the Gut Microbiome to Treat Spontaneous and Induced Murine Models of Colitis.

ABSTRACT:

Background and aims

There is clinical interest in the sustainability or otherwise of prebiotic, microbial, and antibiotic treatments to both prevent and treat inflammatory bowel diseases. This study examined the role of antibiotic manipulation of the gut microbiome to treat spontaneous and induced murine models of colitis.

Methods

Symptomatic, histological, molecular, and microbial ecology and bioinformatic readouts were used to study the effect of a 10-day antibiotic cocktail and then follow-up over 2 months in the spontaneous Winnie colitis mouse preclinical model of ulcerative colitis and also the indirect antibiotic and Winnie microbiotic gavage effects in an acute dextran sodium sulfate-induced colitis model in wild-type mice.

Results

The antibiotics elicited a s

SUBMITTER: Movva R 

PROVIDER: S-EPMC11307790 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature