Circulating IgG4⁺ Plasmablast Count as a Diagnostic Tool in Autoimmune Pancreatitis.

ABSTRACT:

Background & aims

Type 1 autoimmune pancreatitis (AIP) is an IgG4-related disease whose diagnosis is challenging. The aim of this study was to investigate the diagnostic value of circulating total and IgG4⁺ plasmablasts in differentiating this condition from the other main pancreatic diseases.

Methods

Patients with type 1 AIP (n = 19) were prospectively enrolled in a tertiary center together with patients suffering from type 2 or not otherwise specified (NOS) AIP (n = 10), pancreatic adenocarcinoma (n = 17), chronic pancreatitis (n = 20), and intraductal papillary mucinous neoplasia or chronic asymptomatic pancreatic hyperenzymemia (n = 21) as control groups. Flow cytometry was used to measure the total plasmablast and IgG4⁺ plasmablast number by gating

SUBMITTER: Ciccocioppo R 

PROVIDER: S-EPMC11307817 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature