Surveillance Outcomes in Patients With a Family History of Colorectal Cancer in Both Parents.

ABSTRACT:

Background and aims

A family history of colorectal cancer (CRC) in a first-degree relative is a well-established risk factor for CRC. When individuals have 2 parents with CRC, the impact on risk is uncertain, and there are no established guidelines for surveillance. We sought to define the surveillance practices and outcomes in individuals with a family history of CRC in both parents.

Methods

We identified probands with a family history of CRC in both parents from our Hereditary Gastrointestinal Cancer Database. Charts were retrospectively reviewed for colonoscopy surveillance patterns and incidence of adenomas and CRC.

Results

Sixty-six patients met the inclusion criteria. Forty-two patients (64%) had genetic testing, and no pathogenic germline mutations were identif

SUBMITTER: Feldman D 

PROVIDER: S-EPMC11307949 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature