Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.

ABSTRACT:

Backgrounds and aims

Hepatocellular carcinoma (HCC) is the most common cancer with a poor prognosis. Identification of an alternative biomarker that can detect early-stage and conventional tumor marker-negative HCC is urgently needed. We found that protein kinase C delta (PKCδ) is specifically secreted from HCC cell lines into extracellular space and contributes to tumor development and that its serum levels were elevated in HCC patients. This study aimed to assess the practical usefulness of serum PKCδ for detecting HCC in chronic liver disease (CLD) patients.

Methods

Serum PKCδ levels in 313 CLD patients with and without HCC (n = 187 and 126, respectively) were measured using a sandwich enzyme-linked immunosorbent assay. The diagnostic performance of PKCδ for HCC was evalu

SUBMITTER: Oikawa T 

PROVIDER: S-EPMC11308090 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature